FORMULATION AND EVALUATION OF HAND SANITIZER GEL BASED ON WHITE MANGROVE LEAF EXTRACT (Avicennia alba Blume)
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Jan 18, 2025
Keywords:
Gel Hand Sanitizer, Avicennia alba Blume, formulation, evaluation test Gel Hand sanitizer, Avicennia alba Blume, formulasi, uji evaluasi.
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Abstract
Gel hand sanitizer is a gel-based hand cleaner used to cleanse or eliminate microorganisms on the hands. The white mangrove plant (Avicennia alba Blume) is a type of mangrove widely distributed throughout Indonesia and is abundant in nature. White mangrove has also been reported to be non-cytotoxic and can be used as a medicinal ingredient. The active compounds responsible for antibacterial properties in white mangrove plants include flavonoids, saponins, and tannins. Hand sanitizer can be made from the leaves of the white mangrove plant. This study aims to formulate a gel hand sanitizer from white mangrove leaf extract and evaluate the gel hand sanitizer formulation using concentrations of 30%, 20%, and 10%. The analysis method used in this research is descriptive. The study results show that the extract can be formulated into a gel preparation, and some formulations meet the evaluation criteria. The formula that meets all the evaluation criteria is F1, while F2 meets the criteria for organoleptic tests, pH tests, viscosity tests, adhesion tests, and homogeneity tests but does not meet the criteria for the spreadability test. On the other hand, F3 meets the criteria for organoleptic tests, pH tests, viscosity tests, and adhesion tests but does not meet the criteria for homogeneity and spreadability tests.
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References
Afianti, H. P., dan M. Murrukmihadi. “Pengaruh Variasi Kadar Gelling Agent HPMC terhadap Sifat Fisik Sediaan Gel Ekstrak Etanolik Daun Kemangi (Ocimum basilicum L)”, Majalah Farmaseutik, Nomor 11, Volume 2, 2015
Ardana, M., Vebry Aeyni., dan Arsyik, I. “Formulasi dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi”, Journal of Tropical Pharmacy Chemistry, Nomor 3, Volume 2, 2015
Bakshi, M., & Chaudhuri, P. “Antimicrobial potential of leaf extracts of ten mangrove species from Indian Sundarban”, International Journal of Pharma and Bio Sciences, Nomor 5, Volume 1, 2014
Bandarnayake, WM. “Bioactivities, bioactive compounds and chemical constituents of mangrove plants”, Wetlands Ecology Management, Nomor 7, Volume 10, 2002.
Danata, R. H. “Analisis aktivitas antibakteri ekstrak daun mangrove Avicennia marina dari Kabupaten Trenggalek dan Kabupaten Pasuruan terhadap pertumbuhan Staphylococcus aureus dan Vibrio alginolyticus”, Jurnal Kelautan, Nomor 7, Volume 1, 2014.
Forestryana, D., Fahmi, M. S. & Putri, A. N. “Pengaruh Jenis dan Konsentrasi Gelling Agent pada Karakteristik Formula Gel Antiseptik Ekstrak Etanol 70 % Kulit Buah Pisang Ambon”, Lumbung Farmasi: Jurnal Ilmu Kefarmasian, Nomor 1, Volume 2, 2020.
Hariningsih, Y. “Pengaruh Variasi Konsentrasi Na-CMC Terhadap Stabilitas Fisik Gel Ekstrak Pelepah Pisang Ambon (Musa paradisiaca L.)”, Politeknik Harapan Bersama Tegal, Volume 8, Nomor 2, 2019.
Irianto, I. D. K., Purwanto, P., & Mardan, M. T. “Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi”, Majalah Farmaseutik, Volume 16, Nomor 2, 2020.
Kusuma, T. M., Azalea, M., Dianita, P. S., & Syifa, N. “The effect of the variations in type and concentration of gelling agent to the physical properties of hydrocortisone”, Jurnal Farmasi Sains dan Praktis, Volume 4, Nomor 1, 2018
Nabela, W. “Formulasi Dan Uji Sifat Fisik Gel Hand Sanitizer Dari Ekstrak Daun Kedondong”, Karya Tulis Ilmiah, Universitas Muhammadiyah Banjarmasin: Banjarmasin. Hal 33. 2017.
Nikam, S. “Anti-acne Gel of Isotretinoin: Formulation and Evaluation”, Asian Journal Pharmacy Clinic Research, Volume 10, Nomor 11, 2017.
Noor YR, Khazali M, Syadipura INN. Panduan Pengenalan Mangrove di Indonesia. Bogor: Penerbit Wetlands International, 2006
Numberi, A., M., Rani, D., & Elsye, G. “Uji stabilitas fisik sediaan masker gel dari ekstrak alga merah (Poryphyra sp)”, Majalah farmasetika, Volume 5, Nomor 1, 2020
Rohmani, S., & Kuncoro, M. A. A. “Uji Stabilitas dan Aktivitas Gel andsanitizer Ekstrak Daun Kemangi”, JPSCR : Journal of Pharmaceutical Science and Clinical Research, Volume 4, Nomor 1, 2019.
Saraung, Veronika., Paulina V. Yamlean., Gayatri Citraningtyas. “Pengaruh Variasi Babis Karbopol dan HPMC pada Formulasi Gel Ekstrak Etanol Tapak Kuda (Ipomoea pescaprae (L.) R. Br dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus”, Pharmacon Jurnal Ilmiah Farmasi Volume 7, Nomor 3, 2018.
Sarlina, Razak, A. R., & Tandah, M. R. Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Sereh (Cymbopogon nardus L. Rendle) terhadap Bakteri Staphylococcus aureus Penyebab Jerawat. Skripsi. Jurusan Farmasi, Fakultas MIPA, 143 – 149, 2017
Sayuti, NA. “Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.)”, Jurnal Kefarmasian Indonesia, Volume 5, Nomor 2, 2015.
Shadariah M, A. Aziz and T.M. Tengku Sifzizul. Cytotoxicity Assay Activity of Methanol Extract of Mangroves Leaves. Malaysia : Peninsular Malaysia. UMTAS, 2011
Su’aida, N., Destria, I. S., Mia, F. “Optimasi Sediaan Gel Fraksi Etil Asetat Buah Kasturi (Mangifera casturi Kosterm) dengan Kombinasi Basis CMC-Na dan Carbopol Menggunakan Metode Simplex Lattice Design”, Journal of Current Pharmaceutical Sciences, Volume 1, Nomor 1, 2017.
Titaley, S., Fatimawali., Lolo, W. A. “Formulasi dan Uji Efektivitas Sediaan Gel Ekstrak Etanol Daun Mangrove Api-api (Avicennia marina)”, Pharmacon Jurnal Ilmiah Farmasi- UNSRAT, Volume 3, Nomoro 2, 2014.
Wibowo, C., Kusmana, C., Suryani, A., Hartati, Y., & Oktadiyani, P. Pemanfaatan pohon mangrove api-api (Avicennia alba.) sebagai bahan pangan dan obat. Skripsi. Institut Pertanian Bogor, 2009.
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Main Article Content
Abstract
Gel hand sanitizer is a gel-based hand cleaner used to cleanse or eliminate microorganisms on the hands. The white mangrove plant (Avicennia alba Blume) is a type of mangrove widely distributed throughout Indonesia and is abundant in nature. White mangrove has also been reported to be non-cytotoxic and can be used as a medicinal ingredient. The active compounds responsible for antibacterial properties in white mangrove plants include flavonoids, saponins, and tannins. Hand sanitizer can be made from the leaves of the white mangrove plant. This study aims to formulate a gel hand sanitizer from white mangrove leaf extract and evaluate the gel hand sanitizer formulation using concentrations of 30%, 20%, and 10%. The analysis method used in this research is descriptive. The study results show that the extract can be formulated into a gel preparation, and some formulations meet the evaluation criteria. The formula that meets all the evaluation criteria is F1, while F2 meets the criteria for organoleptic tests, pH tests, viscosity tests, adhesion tests, and homogeneity tests but does not meet the criteria for the spreadability test. On the other hand, F3 meets the criteria for organoleptic tests, pH tests, viscosity tests, and adhesion tests but does not meet the criteria for homogeneity and spreadability tests.
Article Details
References
Afianti, H. P., dan M. Murrukmihadi. “Pengaruh Variasi Kadar Gelling Agent HPMC terhadap Sifat Fisik Sediaan Gel Ekstrak Etanolik Daun Kemangi (Ocimum basilicum L)”, Majalah Farmaseutik, Nomor 11, Volume 2, 2015
Ardana, M., Vebry Aeyni., dan Arsyik, I. “Formulasi dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi”, Journal of Tropical Pharmacy Chemistry, Nomor 3, Volume 2, 2015
Bakshi, M., & Chaudhuri, P. “Antimicrobial potential of leaf extracts of ten mangrove species from Indian Sundarban”, International Journal of Pharma and Bio Sciences, Nomor 5, Volume 1, 2014
Bandarnayake, WM. “Bioactivities, bioactive compounds and chemical constituents of mangrove plants”, Wetlands Ecology Management, Nomor 7, Volume 10, 2002.
Danata, R. H. “Analisis aktivitas antibakteri ekstrak daun mangrove Avicennia marina dari Kabupaten Trenggalek dan Kabupaten Pasuruan terhadap pertumbuhan Staphylococcus aureus dan Vibrio alginolyticus”, Jurnal Kelautan, Nomor 7, Volume 1, 2014.
Forestryana, D., Fahmi, M. S. & Putri, A. N. “Pengaruh Jenis dan Konsentrasi Gelling Agent pada Karakteristik Formula Gel Antiseptik Ekstrak Etanol 70 % Kulit Buah Pisang Ambon”, Lumbung Farmasi: Jurnal Ilmu Kefarmasian, Nomor 1, Volume 2, 2020.
Hariningsih, Y. “Pengaruh Variasi Konsentrasi Na-CMC Terhadap Stabilitas Fisik Gel Ekstrak Pelepah Pisang Ambon (Musa paradisiaca L.)”, Politeknik Harapan Bersama Tegal, Volume 8, Nomor 2, 2019.
Irianto, I. D. K., Purwanto, P., & Mardan, M. T. “Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi”, Majalah Farmaseutik, Volume 16, Nomor 2, 2020.
Kusuma, T. M., Azalea, M., Dianita, P. S., & Syifa, N. “The effect of the variations in type and concentration of gelling agent to the physical properties of hydrocortisone”, Jurnal Farmasi Sains dan Praktis, Volume 4, Nomor 1, 2018
Nabela, W. “Formulasi Dan Uji Sifat Fisik Gel Hand Sanitizer Dari Ekstrak Daun Kedondong”, Karya Tulis Ilmiah, Universitas Muhammadiyah Banjarmasin: Banjarmasin. Hal 33. 2017.
Nikam, S. “Anti-acne Gel of Isotretinoin: Formulation and Evaluation”, Asian Journal Pharmacy Clinic Research, Volume 10, Nomor 11, 2017.
Noor YR, Khazali M, Syadipura INN. Panduan Pengenalan Mangrove di Indonesia. Bogor: Penerbit Wetlands International, 2006
Numberi, A., M., Rani, D., & Elsye, G. “Uji stabilitas fisik sediaan masker gel dari ekstrak alga merah (Poryphyra sp)”, Majalah farmasetika, Volume 5, Nomor 1, 2020
Rohmani, S., & Kuncoro, M. A. A. “Uji Stabilitas dan Aktivitas Gel andsanitizer Ekstrak Daun Kemangi”, JPSCR : Journal of Pharmaceutical Science and Clinical Research, Volume 4, Nomor 1, 2019.
Saraung, Veronika., Paulina V. Yamlean., Gayatri Citraningtyas. “Pengaruh Variasi Babis Karbopol dan HPMC pada Formulasi Gel Ekstrak Etanol Tapak Kuda (Ipomoea pescaprae (L.) R. Br dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus”, Pharmacon Jurnal Ilmiah Farmasi Volume 7, Nomor 3, 2018.
Sarlina, Razak, A. R., & Tandah, M. R. Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Sereh (Cymbopogon nardus L. Rendle) terhadap Bakteri Staphylococcus aureus Penyebab Jerawat. Skripsi. Jurusan Farmasi, Fakultas MIPA, 143 – 149, 2017
Sayuti, NA. “Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.)”, Jurnal Kefarmasian Indonesia, Volume 5, Nomor 2, 2015.
Shadariah M, A. Aziz and T.M. Tengku Sifzizul. Cytotoxicity Assay Activity of Methanol Extract of Mangroves Leaves. Malaysia : Peninsular Malaysia. UMTAS, 2011
Su’aida, N., Destria, I. S., Mia, F. “Optimasi Sediaan Gel Fraksi Etil Asetat Buah Kasturi (Mangifera casturi Kosterm) dengan Kombinasi Basis CMC-Na dan Carbopol Menggunakan Metode Simplex Lattice Design”, Journal of Current Pharmaceutical Sciences, Volume 1, Nomor 1, 2017.
Titaley, S., Fatimawali., Lolo, W. A. “Formulasi dan Uji Efektivitas Sediaan Gel Ekstrak Etanol Daun Mangrove Api-api (Avicennia marina)”, Pharmacon Jurnal Ilmiah Farmasi- UNSRAT, Volume 3, Nomoro 2, 2014.
Wibowo, C., Kusmana, C., Suryani, A., Hartati, Y., & Oktadiyani, P. Pemanfaatan pohon mangrove api-api (Avicennia alba.) sebagai bahan pangan dan obat. Skripsi. Institut Pertanian Bogor, 2009.